Branko Cirovic, L. Charlotte J. de Bree, Laszlo Groh, Nigel Curtis, Mihai G. Netea & Andreas Schlitzer investigate the effects of BCG vaccination in humans and reveal the induction of a transcriptomic rewiring of human stem and progenitor cells toward the myeloid cell lineage, instructed by hepatic nuclear factors, resulting in epigenetic and functional changes within CD14+ peripheral monocytes.

BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment: Cell Host & Microbe

👥 Auteurs ( 🎓 University of Bonn, 🎓 Radboud University, 🎓 Murdoch Childrens Research Institute, 🎓 University of Southern Denmark ): 👤 Branko Cirovic, 👤 L. Charlotte J. de Bree, 👤 Laszlo Groh, 👤 Bas A. Blok, 👤 Joyce Chan, 👤 Walter J.F.M. van der Velden, 👤 M.E.J. Bremmers, 👤 Reinout van Crevel, 👤 Kristian Händler, 👤 Simone Picelli, 👤 Jonas Schulte-Schrepping, 👤 Kathrin Klee, 👤 Marije Oosting, 👤 Valerie A.C.M. Koeken, 👤 Jakko van Ingen, 👤 Yang Li, 👤 Christine S. Benn, 👤 Joachim L. Schultze, 👤 Leo A.B. Joosten, 👤 Nigel Curtis, 👤 Mihai G. Netea & 👤 Andreas Schlitzer.

💬 Laisser un commentaire